How does sotrovimab work?
Sotrovimab binds to the spike protein of the SARS-CoV-2 virus, preventing it from entering human cells and stopping the infection from spreading.
What is sotrovimab used to treat?
Sotrovimab is commonly prescribed for:
- Mild to moderate COVID-19 in high-risk individuals (to prevent severe illness and hospitalisation)
- People with weakened immune systems (who are less able to fight COVID-19 naturally)
Who can take sotrovimab?
Sotrovimab is suitable for most adults and some children over 12 years old who are at high risk of severe COVID-19.
Who might not be able to take sotrovimab?
Sotrovimab may not be suitable if you:
- Have a known allergy to monoclonal antibodies
- Have already progressed to severe COVID-19 requiring hospitalisation
- Are taking certain medications that may interact with monoclonal antibody treatments
Can I take sotrovimab if I’m pregnant or breastfeeding?
Sotrovimab may be used during pregnancy and breastfeeding if the benefits outweigh the risks. Speak to your doctor for advice.
What if I miss a dose?
Sotrovimab is given as a single infusion, so missing a dose is not usually an issue. If you were scheduled for a dose but missed it, contact your healthcare provider.
How effective is sotrovimab?
Sotrovimab is highly effective at reducing the risk of hospitalisation and severe illness when given early in COVID-19 infection.
What should I do if I take too much?
Sotrovimab is administered by a healthcare professional, but if you experience severe side effects after treatment, seek urgent medical help.
What dose of sotrovimab is usually taken?
- For COVID-19 treatment: A single 500mg infusion, given over 30 minutes in a healthcare setting
Your doctor will determine if you are eligible for treatment.
What are the side effects of sotrovimab?
Common side effects include:
- Infusion-related reactions (fever, chills, dizziness)
- Nausea
- Headache
- Skin rash or irritation
Serious side effects, such as severe allergic reactions or breathing difficulties, require urgent medical attention.
How should I take sotrovimab?
Sotrovimab is given as a single intravenous (IV) infusion by a healthcare professional.
When should sotrovimab be taken?
Sotrovimab should be given as soon as possible after a confirmed COVID-19 diagnosis, ideally within five days of symptom onset.
What are the brand names for sotrovimab?
Sotrovimab is available under the brand name:
- Xevudy
Final thoughts
Sotrovimab is an effective treatment for high-risk COVID-19 patients, but it should be given as early as possible to maximise its benefits. If you have any concerns about your treatment, speak to your doctor.
