How does mesalazine work?
Mesalazine reduces inflammation in the lining of the intestines, helping to control flare-ups of ulcerative colitis and Crohn’s disease and maintain remission.
What is mesalazine used to treat?
Mesalazine is commonly prescribed for:
- Ulcerative colitis (to reduce inflammation and prevent flare-ups)
- Crohn’s disease (to manage symptoms in mild to moderate cases)
- Inflammatory bowel disease (IBD) (to help control long-term gut inflammation)
Who can take mesalazine?
Mesalazine is suitable for most adults and some children, as prescribed by a doctor.
Who might not be able to take mesalazine?
Mesalazine may not be suitable if you:
- Have severe kidney or liver disease
- Have a known allergy to salicylates (such as aspirin)
- Have a history of blood disorders
Can I take mesalazine if I’m pregnant or breastfeeding?
Mesalazine may be used during pregnancy and breastfeeding, but your doctor will assess the benefits and risks before prescribing it.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is mesalazine?
Mesalazine is highly effective at reducing inflammation and preventing relapses in ulcerative colitis when taken as prescribed.
What should I do if I take too much?
Taking too much mesalazine can cause nausea, vomiting, stomach pain, or kidney problems. If you think you’ve taken too much, seek medical advice immediately.
What dose of mesalazine is usually taken?
- For active ulcerative colitis: 2g to 4g daily, divided into smaller doses
- For maintenance treatment: 1.2g to 2.4g daily
Your doctor will determine the correct dose based on your condition.
What are the side effects of mesalazine?
Common side effects include:
- Nausea or stomach pain
- Headache
- Diarrhoea or bloating
- Rash or itching
Serious side effects, such as kidney problems, liver issues, or unusual bruising, require urgent medical attention.
How should I take mesalazine?
Mesalazine is available as tablets, granules, suppositories, or enemas. Follow your doctor’s instructions carefully.
When should mesalazine be taken?
Mesalazine should be taken at the same time each day, with or without food, depending on the formulation.
What are the brand names for mesalazine?
Mesalazine is available as a generic medicine, but some branded versions include:
- Asacol
- Pentasa
- Mezavant
- Salofalk
Final thoughts
Mesalazine is an effective treatment for ulcerative colitis and Crohn’s disease, but it should be taken exactly as prescribed. Regular monitoring of kidney function may be required. If side effects occur, speak to your doctor or pharmacist.
