How does sacubitril work?
Sacubitril blocks an enzyme called neprilysin, which increases the levels of certain beneficial substances that relax blood vessels and reduce fluid build-up, easing strain on the heart.
What is sacubitril used to treat?
Sacubitril is commonly prescribed, combined with valsartan, for:
- Chronic heart failure (particularly heart failure with reduced ejection fraction)
Who can take sacubitril?
Sacubitril is suitable for adults diagnosed with chronic heart failure. Your doctor will determine if it is appropriate based on your specific condition.
Who might not be able to take sacubitril?
Sacubitril may not be suitable if you:
- Have previously experienced angioedema (severe swelling) due to medicines
- Have severe liver disease
- Are pregnant or planning pregnancy
- Are taking ACE inhibitors (another type of heart medication)
Can I take sacubitril if I’m pregnant or breastfeeding?
Sacubitril should not be used during pregnancy due to potential harm to the baby. It’s also generally not recommended while breastfeeding—always speak with your doctor.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed one—do not take two doses at once.
How effective is sacubitril?
Sacubitril combined with valsartan significantly reduces hospitalisation and improves outcomes for people with chronic heart failure.
What should I do if I take too much?
Taking too much sacubitril can lead to dizziness, low blood pressure, or fainting. Seek immediate medical attention if you suspect an overdose.
What dose of sacubitril is usually taken?
Typically prescribed as a combination tablet with valsartan:
- Starting dose is usually one tablet twice daily (dose varies based on individual condition)
Your doctor will gradually adjust the dose depending on your response
Always follow your doctor’s specific instructions.
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What are the side effects of sacubitril?
Common side effects include:
- Low blood pressure (dizziness)
- High potassium levels
- Cough
- Kidney problems
Serious side effects requiring urgent attention:
- Swelling of face, lips, or throat (angioedema)
- Severe allergic reactions
How should I take sacubitril?
Sacubitril comes as a combined tablet with valsartan. Swallow the tablet whole with water, with or without food.
When should sacubitril be taken?
Sacubitril is usually taken twice daily, ideally at the same times each day to maintain consistent medication levels.
What are the brand names for sacubitril?
Sacubitril combined with valsartan is known by the brand name:
- Entresto
Final thoughts
Sacubitril, combined with valsartan, can significantly improve quality of life and outcomes in heart failure patients. Always follow your doctor’s advice, and speak to them if you have any concerns or experience side effects.
