Persistent Trophoblastic Disease (Choriocarcinoma)

Persistent trophoblastic disease, also known as choriocarcinoma, is a rare type of cancer that can occur after pregnancy. It develops from a tissue that normally forms the placenta.

What is persistent trophoblastic disease (choriocarcinoma)?

Persistent trophoblastic disease refers to a group of conditions that arise when cells that usually help to support a pregnancy turn into cancerous cells. Choriocarcinoma is one type of this disease and can develop after a pregnancy, particularly if there were complications.

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What are the symptoms of persistent trophoblastic disease (choriocarcinoma)?

The symptoms of choriocarcinoma can vary and may include:

  • Abnormal bleeding from the vagina, which may happen after a pregnancy
  • Pelvic pain
  • A swollen abdomen or feeling of fullness
  • Nausea and vomiting
  • Shortness of breath if the cancer has spread to the lungs
  • Unexplained weight loss

What causes persistent trophoblastic disease (choriocarcinoma)?

The exact cause of choriocarcinoma is not clear. It often develops from a condition called a hydatidiform mole, which is an abnormal growth of tissue in the uterus that can happen during pregnancy. Sometimes it can also arise after a normal pregnancy.

How common is persistent trophoblastic disease (choriocarcinoma)?

Choriocarcinoma is considered rare. It is more common in certain populations and typically occurs in women during their childbearing years. The risk factors include:

  • A history of molar pregnancy
  • Older age at pregnancy
  • Having multiple pregnancies

How can I treat persistent trophoblastic disease (choriocarcinoma)?

Choriocarcinoma is usually treated with a combination of surgery and chemotherapy. Treatment plans vary depending on how advanced the cancer is, but options may include:

  • Removing the tumour through surgery
  • Using medicines to kill cancer cells

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Final thoughts

Choriocarcinoma is a serious condition, but effective treatment is available. If you have any concerns or symptoms, it’s important to speak to your GP or healthcare provider as soon as possible.

Always consult a medical professional
This article is for informational purposes only and is not a substitute for medical advice. Always consult a healthcare professional before starting, stopping or changing any medication. If you have concerns about your medication or experience side effects, speak to your doctor or pharmacist immediately.

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