Primary Biliary Cirrhosis (PBC)

Primary biliary cirrhosis (PBC) is a chronic disease that affects the liver. It occurs when the small bile ducts in the liver become damaged, leading to liver problems over time.

What is primary biliary cirrhosis (PBC)?

Primary biliary cirrhosis (PBC) is a long-term disease of the liver. It mainly affects the bile ducts, which help carry bile, a substance that helps digest food, from the liver to the intestine. When these ducts are damaged, bile builds up in the liver, causing inflammation and damage to liver cells.

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What are the symptoms of PBC?

The symptoms of PBC can develop slowly and might vary from person to person. Here are some common symptoms:

  • Tiredness or fatigue
  • Itchy skin
  • Dry eyes and mouth
  • Pain in the upper right side of the abdomen
  • Yellowing of the skin and eyes (jaundice)
  • Swelling in the legs and belly
  • Dark urine and pale stools

What causes PBC?

The exact cause of PBC is not fully understood. It is thought to be an autoimmune condition, which means the body’s immune system mistakenly attacks healthy cells. Factors that may contribute include:

  • Genetic factors (family history)
  • Infections
  • Certain environmental factors

How common is PBC?

PBC is considered relatively rare. It mainly affects middle-aged women, although men can also develop the condition. Estimates suggest that around 1 in every 10,000 people have PBC in the UK.

Who is more likely to get PBC?

There are several factors that may increase the risk of developing PBC:

  • Being female
  • Aging (most common in people aged 30 to 60)
  • A family history of autoimmune diseases
  • Having other autoimmune conditions, such as thyroid disease or rheumatoid arthritis

How can I treat PBC?

While there is no cure for PBC, treatment can help manage symptoms and slow down the progression of the disease. Common treatments include:

  • Medications to reduce itching
  • Supplements to support liver health
  • Regular monitoring by a healthcare provider

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How to live with PBC?

Living with PBC can be challenging, but there are ways to manage the condition. It’s important to:

  • Maintain a healthy diet
  • Exercise regularly, as tolerated
  • Stay hydrated
  • Avoid alcohol and certain medications that can harm the liver
  • Attend regular check-ups with your healthcare provider

What support is available for people with PBC?

Support is important for managing a chronic condition like PBC. You can seek help through:

  • Support groups for people with liver conditions
  • Counseling services for emotional support
  • Your healthcare provider for information and resources

Final thoughts

PBC is a serious condition that requires ongoing management. If you have any concerns about your health or symptoms, it’s important to speak with your GP or healthcare provider.

Sources

Always consult a medical professional
This article is for informational purposes only and is not a substitute for medical advice. Always consult a healthcare professional before starting, stopping or changing any medication. If you have concerns about your medication or experience side effects, speak to your doctor or pharmacist immediately.

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