How does azathioprine work?
Azathioprine inhibits the production of certain white blood cells, helping to reduce inflammation and prevent the immune system from attacking the body’s own tissues.
What is azathioprine used to treat?
Azathioprine is commonly prescribed for:
Autoimmune conditions, such as rheumatoid arthritis, lupus, and Crohn’s disease
Inflammatory bowel disease (IBD) (such as ulcerative colitis and Crohn’s disease)
Preventing organ rejection after a kidney, liver, or heart transplant
Severe eczema or other inflammatory skin conditions
Who can take azathioprine?
Azathioprine is suitable for most adults and children with autoimmune diseases or organ transplants, as prescribed by a doctor.
Who might not be able to take azathioprine?
Azathioprine may not be suitable if you:
Have liver disease
Have a history of blood disorders
Have a weakened immune system
Are taking medications that affect the immune system (such as allopurinol)
Can I take azathioprine if I’m pregnant or breastfeeding?
Azathioprine is sometimes used during pregnancy and breastfeeding, but only under strict medical supervision. Speak to your doctor before use.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is azathioprine?
Azathioprine is highly effective at managing autoimmune diseases and preventing organ rejection when taken consistently as prescribed.
What should I do if I take too much?
Taking too much azathioprine can cause severe side effects, including nausea, infections, or liver problems. If you think you’ve taken too much, seek medical help immediately.
What dose of azathioprine is usually taken?
For autoimmune diseases: 1mg to 3mg per kg of body weight daily
For transplant patients: 1mg to 5mg per kg of body weight daily
Your doctor will determine the correct dose based on your condition and response to treatment.
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What are the side effects of azathioprine?
Common side effects include:
Nausea or vomiting
Increased risk of infections
Fatigue
Loss of appetite
Serious side effects, such as severe infections, liver damage, or unusual bruising, require urgent medical attention.
How should I take azathioprine?
Azathioprine is taken as tablets or injections, usually once daily with food to reduce stomach upset.
When should azathioprine be taken?
Azathioprine should be taken at the same time each day, with or without food.
What are the brand names for azathioprine?
Azathioprine is available as a generic medicine, but some branded versions include:
Imuran
Azapress
Final thoughts
Azathioprine is an effective immunosuppressant for managing autoimmune conditions and preventing organ rejection, but it should be taken exactly as prescribed. Regular blood tests are required to monitor your response. If side effects occur, speak to your doctor or pharmacist.
