How does donepezil work?
Donepezil prevents the breakdown of acetylcholine, a neurotransmitter that helps with memory and thinking. Increasing acetylcholine levels may temporarily improve brain function in people with dementia.
What is donepezil used to treat?
Donepezil is commonly prescribed for:
- Mild to moderate Alzheimer’s disease (to improve cognitive function)
- Severe Alzheimer’s disease (to help maintain daily function for as long as possible)
Who can take donepezil?
Donepezil is suitable for most adults diagnosed with Alzheimer’s disease.
Who might not be able to take donepezil?
Donepezil may not be suitable if you:
- Have heart rhythm problems (such as slow heartbeat)
- Have stomach ulcers or digestive issues
- Have asthma or chronic lung disease
- Have liver disease
Can I take donepezil if I’m pregnant or breastfeeding?
Donepezil isn’t usually prescribed during pregnancy or breastfeeding, as it is intended for dementia treatment.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is donepezil?
Donepezil does not cure Alzheimer’s disease, but it can temporarily slow cognitive decline and help with daily activities.
What should I do if I take too much?
Taking too much donepezil can cause nausea, vomiting, fainting, seizures, or severe muscle weakness. If you think you’ve taken too much, seek emergency medical help immediately.
What dose of donepezil is usually taken?
- Starting dose: 5mg once daily
- Maintenance dose: 5mg to 10mg once daily for mild to moderate Alzheimer’s
- For severe Alzheimer’s: Up to 23mg once daily, as prescribed
Your doctor will determine the correct dose based on your condition.
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What are the side effects of donepezil?
Common side effects include:
- Nausea or diarrhoea
- Dizziness or fainting
- Loss of appetite
- Insomnia or vivid dreams
- Muscle cramps
Serious side effects, such as severe dizziness, seizures, or difficulty breathing, require urgent medical attention.
How should I take donepezil?
Donepezil is taken as tablets or dissolvable tablets, usually once daily before bedtime.
When should donepezil be taken?
Donepezil is usually taken at night before bed, as it can cause dizziness.
What are the brand names for donepezil?
Donepezil is available as a generic medicine, but some branded versions include:
- Aricept
- Aricept Evess (orodispersible tablets)
Final thoughts
Donepezil is an effective treatment for managing Alzheimer’s symptoms, but it does not stop disease progression. To get the best results, take it as prescribed, and if side effects occur, speak to your doctor or pharmacist.
