How does methadone work?
Methadone binds to opioid receptors in the brain, reducing withdrawal symptoms, cravings, and pain without causing the same high as other opioids.
What is methadone used to treat?
Methadone is commonly prescribed for:
- Opioid dependence (to reduce cravings and withdrawal symptoms in people addicted to heroin or other opioids)
- Severe pain (when other painkillers are not effective or suitable)
Who can take methadone?
Methadone is suitable for most adults with opioid addiction or chronic pain, as prescribed by a doctor.
Who might not be able to take methadone?
Methadone may not be suitable if you:
- Have severe breathing problems (such as COPD or sleep apnoea)
- Have a history of heart problems or irregular heartbeats (QT prolongation)
- Have liver disease
- Have a history of drug or alcohol misuse (without supervision)
Can I take methadone if I’m pregnant or breastfeeding?
Methadone is sometimes prescribed during pregnancy and breastfeeding for opioid dependence, but it must be carefully monitored by a doctor.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is methadone?
Methadone is highly effective at reducing opioid cravings, preventing withdrawal symptoms, and providing long-lasting pain relief when taken as prescribed.
What should I do if I take too much?
Taking too much methadone can cause severe drowsiness, slow breathing, unconsciousness, or overdose. If you think you’ve taken too much, seek emergency medical help immediately.
What dose of methadone is usually taken?
- For opioid dependence: Usually 10mg to 40mg once daily, adjusted based on response
- For severe pain: 2.5mg to 10mg every 8 to 12 hours, as prescribed
Your doctor will determine the correct dose based on your condition and response.
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What are the side effects of methadone?
Common side effects include:
- Drowsiness or dizziness
- Nausea or vomiting
- Constipation
- Sweating
Serious side effects, such as breathing difficulties, severe drowsiness, or irregular heartbeats, require urgent medical attention.
How should I take methadone?
Methadone is taken as liquid, tablets, or injections, usually once daily for opioid dependence or at prescribed intervals for pain relief.
When should methadone be taken?
Methadone should be taken at the same time each day, with or without food, as directed by your doctor.
What are the brand names for methadone?
Methadone is available as a generic medicine, but some branded versions include:
- Physeptone
- Methadose (outside the UK)
Final thoughts
Methadone is an effective treatment for opioid dependence and chronic pain, but it must be taken exactly as prescribed due to the risk of dependence and overdose. Regular monitoring may be needed. If side effects occur, speak to your doctor or pharmacist.
