Why was ranitidine withdrawn?
Ranitidine was withdrawn from the market in 2020 after studies found it could contain N-nitrosodimethylamine (NDMA), a substance that may increase the risk of cancer. As a result, its use has been discontinued in the UK, the US, and other countries.
What conditions was ranitidine used to treat?
Before its withdrawal, ranitidine was commonly prescribed for:
- Acid reflux and heartburn (gastroesophageal reflux disease, GERD)
- Stomach and duodenal ulcers
- Zollinger-Ellison syndrome (a rare condition causing excessive stomach acid production)
- Preventing acid-related damage in people taking NSAIDs (such as ibuprofen)
What are the alternatives to ranitidine?
Since ranitidine is no longer available, doctors may prescribe alternative medications, such as:
- Proton pump inhibitors (PPIs) (such as omeprazole, lansoprazole, or pantoprazole)
- Other H2 receptor antagonists (such as famotidine, which is considered safer)
- Lifestyle changes (such as avoiding acidic foods, eating smaller meals, and elevating the head while sleeping)
Who might not be able to take alternatives to ranitidine?
Some alternative medications may not be suitable if you:
- Have severe liver disease
- Have osteoporosis or a history of fractures (long-term PPI use may increase this risk)
- Are taking other medications that interact with PPIs or H2 blockers
Can I take alternatives if I’m pregnant or breastfeeding?
Some PPIs and H2 blockers may be used during pregnancy and breastfeeding, but always check with your doctor first.
Final thoughts
Ranitidine is no longer available due to safety concerns, but there are alternative treatments for acid reflux and stomach ulcers. If you were previously taking ranitidine, speak to your doctor or pharmacist about safer options.
