How does simvastatin work?
Simvastatin blocks an enzyme in the liver (HMG-CoA reductase) that is responsible for producing cholesterol. This helps lower LDL (‘bad’ cholesterol) and triglycerides while increasing HDL (‘good’ cholesterol).
What is simvastatin used to treat?
Simvastatin is commonly prescribed for:
- High cholesterol (hypercholesterolaemia) (to reduce the risk of heart disease and stroke)
- Familial hypercholesterolaemia (a genetic condition causing high cholesterol levels)
- Preventing cardiovascular disease (in people at high risk of heart attacks and strokes)
Who can take simvastatin?
Simvastatin is suitable for most adults and some children (under specialist supervision) who need cholesterol management.
Who might not be able to take simvastatin?
Simvastatin may not be suitable if you:
- Have liver disease
- Have severe kidney disease
- Have a history of muscle problems or myopathy
- Are taking certain medications that interact with statins (such as ciclosporin or fibrates)
Can I take simvastatin if I’m pregnant or breastfeeding?
Simvastatin isn’t recommended during pregnancy or breastfeeding, as it may affect the baby. Speak to your doctor about safer alternatives.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is simvastatin?
Simvastatin is highly effective at lowering cholesterol levels and reducing cardiovascular risk when taken consistently.
What should I do if I take too much?
Taking too much simvastatin can increase the risk of serious side effects, including muscle pain and liver damage. If you think you’ve taken too much, seek medical help immediately.
What dose of simvastatin is usually taken?
- Starting dose: 10mg to 20mg once daily
- Maintenance dose: 10mg to 80mg once daily
Your doctor will determine the correct dose based on your cholesterol levels and overall health.
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What are the side effects of simvastatin?
Common side effects include:
- Headache
- Muscle pain or weakness
- Nausea or stomach discomfort
- Dizziness
Serious side effects, such as severe muscle pain (rhabdomyolysis) or liver problems, require urgent medical attention.
How should I take simvastatin?
Simvastatin is taken as tablets, usually once daily, with or without food.
When should simvastatin be taken?
Simvastatin should be taken at the same time each day, preferably in the evening.
What are the brand names for simvastatin?
Simvastatin is available as a generic medicine, but some branded versions include:
- Zocor
- Inegy (combined with ezetimibe)
Final thoughts
Simvastatin is an effective cholesterol-lowering medication that reduces the risk of heart disease and strokes. To get the best results, take it as prescribed, maintain a healthy diet, and have regular cholesterol checks. If side effects occur, speak to your doctor or pharmacist.
