How does sitagliptin work?
Sitagliptin enhances the effects of incretin hormones, which help the pancreas release more insulin and decrease glucose production by the liver, leading to better blood sugar control.
What is sitagliptin used to treat?
Sitagliptin is commonly prescribed for:
- Type 2 diabetes (to improve blood sugar control when diet and exercise alone are not enough)
- Combination therapy (often used with other diabetes medications such as metformin)
Who can take sitagliptin?
Sitagliptin is suitable for most adults with type 2 diabetes, as prescribed by a doctor.
Who might not be able to take sitagliptin?
Sitagliptin may not be suitable if you:
- Have type 1 diabetes (it is not effective for this type)
- Have a history of pancreatitis
- Have severe kidney disease (dose adjustment may be needed)
- Are taking other medications that affect blood sugar levels
Can I take sitagliptin if I’m pregnant or breastfeeding?
Sitagliptin isn’t usually recommended during pregnancy or breastfeeding. Speak to your doctor about safer alternatives.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is sitagliptin?
Sitagliptin is highly effective at lowering blood sugar levels when combined with a healthy diet and exercise.
What should I do if I take too much?
Taking too much sitagliptin can cause low blood sugar (hypoglycaemia), especially when combined with other diabetes medications. If you experience symptoms like dizziness, sweating, or confusion, eat or drink something sugary and seek medical help if necessary.
What dose of sitagliptin is usually taken?
- For type 2 diabetes: 100mg once daily
- Lower doses (25mg or 50mg) may be used in people with kidney problems
Your doctor will determine the correct dose based on your condition.
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What are the side effects of sitagliptin?
Common side effects include:
- Headache
- Nausea or stomach discomfort
- Cold-like symptoms (blocked nose, sore throat)
- Joint or muscle pain
Serious side effects, such as pancreatitis, severe allergic reactions, or kidney problems, require urgent medical attention.
How should I take sitagliptin?
Sitagliptin is taken as tablets, usually once daily, with or without food.
When should sitagliptin be taken?
Sitagliptin should be taken at the same time each day, as prescribed by your doctor.
What are the brand names for sitagliptin?
Sitagliptin is available as a generic medicine, but some branded versions include:
- Januvia
- Janumet (combined with metformin)
Final thoughts
Sitagliptin is an effective medication for managing type 2 diabetes, but it should be taken exactly as prescribed. Regular monitoring of blood sugar levels is recommended. If side effects occur, speak to your doctor or pharmacist.
