How does sulfasalazine work?
Sulfasalazine reduces inflammation by suppressing the immune system and lowering the production of inflammatory chemicals in the body. This helps ease symptoms of autoimmune conditions.
What is sulfasalazine used to treat?
Sulfasalazine is commonly prescribed for:
- Rheumatoid arthritis (to slow joint damage and reduce inflammation)
- Ulcerative colitis (to relieve symptoms and prevent flare-ups)
- Crohn’s disease (to help manage gut inflammation)
Who can take sulfasalazine?
Sulfasalazine is suitable for most adults and children with inflammatory conditions, as prescribed by a doctor.
Who might not be able to take sulfasalazine?
Sulfasalazine may not be suitable if you:
- Have a known allergy to sulfa drugs or aspirin
- Have severe liver or kidney disease
- Have a blood disorder
- Have glucose-6-phosphate dehydrogenase (G6PD) deficiency
Can I take sulfasalazine if I’m pregnant or breastfeeding?
Sulfasalazine is sometimes used during pregnancy and breastfeeding, but your doctor will assess the risks and benefits.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is sulfasalazine?
Sulfasalazine is highly effective at reducing inflammation and preventing disease progression when taken consistently.
What should I do if I take too much?
Taking too much sulfasalazine can cause nausea, vomiting, or liver problems. If you think you’ve taken too much, seek medical help immediately.
What dose of sulfasalazine is usually taken?
- For rheumatoid arthritis: 500mg to 3g daily, divided into smaller doses
- For ulcerative colitis and Crohn’s disease: 1g to 4g daily, as prescribed
Your doctor will determine the correct dose based on your condition.
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What are the side effects of sulfasalazine?
Common side effects include:
- Nausea or stomach pain
- Headache
- Loss of appetite
- Orange-coloured urine or sweat (harmless side effect)
Serious side effects, such as severe allergic reactions, liver damage, or unusual bruising, require urgent medical attention.
How should I take sulfasalazine?
Sulfasalazine is taken as tablets, usually with food and a full glass of water to reduce stomach upset.
When should sulfasalazine be taken?
Sulfasalazine should be taken at evenly spaced times throughout the day, as prescribed.
What are the brand names for sulfasalazine?
Sulfasalazine is available as a generic medicine, but some branded versions include:
- Salazopyrin
- Azulfidine
Final thoughts
Sulfasalazine is an effective treatment for inflammatory conditions, but it should be taken exactly as prescribed. Regular blood tests may be needed to monitor its effects. If side effects occur, speak to your doctor or pharmacist.
