How does duloxetine work?
Duloxetine increases serotonin and noradrenaline levels in the brain, improving mood and reducing pain signals in conditions like fibromyalgia and diabetic nerve pain.
What is duloxetine used to treat?
Duloxetine is commonly prescribed for:
- Depression
- Generalised anxiety disorder (GAD)
- Nerve pain (diabetic neuropathy, fibromyalgia, or chronic pain conditions)
- Stress urinary incontinence (in some cases)
Who can take duloxetine?
Duloxetine is suitable for most adults aged 18 and over. It is sometimes prescribed for younger people under specialist supervision.
Who might not be able to take duloxetine?
Duloxetine may not be suitable if you:
- Are allergic to duloxetine or similar medications
- Have liver or kidney disease
- Have uncontrolled high blood pressure
- Are taking other antidepressants (such as MAOIs)
Can I take duloxetine if I’m pregnant or breastfeeding?
Duloxetine isn’t usually recommended during pregnancy unless advised by a doctor. If you are pregnant or breastfeeding, speak to a healthcare professional before taking it.
What if I miss a dose?
If you forget to take a dose, take it as soon as you remember. If it’s nearly time for your next dose, skip the missed one – do not take two doses at once.
How effective is duloxetine?
Duloxetine is highly effective at treating depression, anxiety, and nerve pain, but it may take 2 to 4 weeks before you notice significant improvements.
What should I do if I take too much?
Taking too much duloxetine can be dangerous and may cause:
- Drowsiness or confusion
- Seizures
- Irregular heartbeats
If you think you’ve taken too much, seek medical help immediately.
What dose of duloxetine is usually taken?
The usual starting doses are:
- Depression & anxiety: 30mg to 60mg once daily
- Nerve pain & fibromyalgia: 60mg once daily (may increase to 120mg)
Your doctor will determine the best dose for your condition.
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What are the side effects of duloxetine?
Common side effects include:
- Nausea
- Dry mouth
- Drowsiness or dizziness
- Sweating
- Constipation
Some people may experience more serious side effects, such as suicidal thoughts (especially in the first few weeks). If you feel unsafe, seek help immediately.
How should I take duloxetine?
Duloxetine is taken as a capsule, usually once a day, swallowed whole with water.
When should duloxetine be taken?
Duloxetine is usually taken in the morning or evening, depending on how it affects your energy levels.
What are the brand names for duloxetine?
Duloxetine is available under different brand names, including:
- Cymbalta
- Yentreve (used for stress urinary incontinence)
Final thoughts
Duloxetine is an effective treatment for depression, anxiety, and nerve pain. It’s important to take it as prescribed and not stop suddenly without medical advice. If you have concerns about side effects or stopping treatment, speak to your doctor or pharmacist.
