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What antidepressants cause weight loss?

Picture of Andrew Bellingham

Andrew Bellingham

Pharmacist | 20+ Years | BPharm | Dip Clin Pharm

Antidepressants are primarily prescribed to manage mood disorders such as depression and anxiety. While their main function is to improve mental health, some antidepressants can also affect physical health, including weight. It is important to note that antidepressants should not be taken solely for weight loss. This article discusses which antidepressants might lead to weight loss as a side effect, but they should only be used under medical supervision for their intended purpose.

Antidepressants that may cause weight loss

Several antidepressants are known to potentially cause weight loss. These include:

Bupropion (Wellbutrin)

Bupropion is commonly prescribed to treat depression and assist with smoking cessation. Unlike many other antidepressants, it is less likely to cause weight gain and can sometimes lead to weight loss. This effect is likely due to its stimulating properties and influence on neurotransmitters that affect appetite.

Desvenlafaxine (Pristiq)

Desvenlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major depressive disorder. Some users of desvenlafaxine may experience weight loss, although this effect can vary among individuals.

Duloxetine (Cymbalta)

Duloxetine is another SNRI used for depression and anxiety. While it is more commonly associated with weight gain, some individuals may experience weight loss. The impact on weight can differ based on individual response and dosage.

Frequently asked questions about weight loss

Which antidepressants are known to cause weight loss?

Antidepressants that may cause weight loss include bupropion, desvenlafaxine, and duloxetine. Consult your doctor for tailored advice.

How does bupropion lead to weight loss?

Bupropion may cause weight loss by increasing metabolism and reducing appetite. It affects neurotransmitters involved in hunger and energy expenditure.

Can desvenlafaxine or duloxetine cause weight loss?

Desvenlafaxine and duloxetine can sometimes lead to weight loss, though effects vary. Consult your doctor to understand how these medications might affect you.

A man in his 60s is running in the park while listening to music. He has a big grin because his antidepressants are working well.

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