Guide to Switching from Mounjaro to Wegovy

Picture of Ayaz Hussain

Ayaz Hussain

Lead Prescriber, AH UK Pharm Ltd
Switching from Mounjaro (tirzepatide) to Wegovy (semaglutide) is becoming more common, and price changes are one of the key reasons behind it. Other factors, like side effects, new health goals or recommendations from your doctor can also influence the decision. The good news is that moving from one treatment to the other is usually a smooth process with the right medical support and information.

Considering a switch from Mounjaro to Wegovy?

Both medicines belong to a group called GLP-1 receptor agonists, which are designed to help with weight management. Even though they fall under the same category, each works a little differently.

The following are key reasons why people might decide to change to Wegovy:

  • Practical factors can often drive the switch. Cost, supply shortages, or simply preferring the routine of one treatment over another can influence the decision.
  • Side effects are also a common reason. Even though Mounjaro and Wegovy can cause similar issues like nausea or stomach upset, your body may react differently to each. Many people find Weovy easier to tolerate.
  • Switching can help restart progress. If side effects are slowing you down, moving to a different treatment can sometimes make it easier to stay on track with your goals.
  • Wegovy has added heart health benefits. It’s currently the only GLP-1 medicine in the UK approved to reduce the risk of major cardiovascular problems, such as heart attacks and strokes, in people with obesity and existing heart disease.

Ultimately, it’s about what works best for you – finding the right treatment is personal, and safety is always the top priority. With the right medical guidance, switching may help you feel better supported in your long-term health journey.

The prescribing process for Wegovy or Mounjaro is very similar and your eligibility will be determined by the clinician reviewing the information you provide during your assessment.

How to switch

To consult a clinician about switching to Wegovy, please follow the usual process to request it as your next treatment through our website or app. As with all prescription medication, your request will require a full clinical consultation and approval from a prescriber to ensure the switch is safe and appropriate for you.

The recommended dosing when switching to Wegovy is usually as follows, although we evaluate each patient individually:

Current Mounjaro Dose
Wegovy Starting Dose
No current Dose
0.25
2.5mg
0.5mg
5mg
1.0mg
7.5mg
1.0mg
10mg
1.7mg
15mg
1.7mg
*Recommended

What about a break before switching?

No – you don’t need to pause treatment.

After your last Mounjaro dose, you simply start Wegovy the following week on the same injection day. Your clinician will guide you on the right dose and gradually increase it over time to help your body adjust.

Conclusion

Changing weight loss medication is usually a smooth process when guided by a clinician. Before making the switch, it’s important to understand your reasons and make sure the timing is right. A healthcare professional or prescriber can help you weigh up the options and confirm the safest plan for you going forward.

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