How does prochlorperazine work?
Prochlorperazine blocks dopamine receptors in the brain, reducing nausea, vomiting, and dizziness. In higher doses, it can also help manage symptoms of psychosis.
What is prochlorperazine used to treat?
Prochlorperazine is commonly prescribed for:
- Nausea and vomiting (including motion sickness and morning sickness)
- Vertigo and balance disorders (such as labyrinthitis and Ménière’s disease)
- Migraine-associated nausea
- Short-term treatment of anxiety (when other treatments aren’t suitable)
- Certain mental health conditions (such as schizophrenia, though less commonly used for this now)
Who can take prochlorperazine?
Prochlorperazine is suitable for most adults and children over 12 years old for nausea and vomiting, and for mental health conditions under medical supervision.
Who might not be able to take prochlorperazine?
Prochlorperazine may not be suitable if you:
- Have Parkinson’s disease
- Have severe liver disease
- Have epilepsy or a history of seizures
- Have narrow-angle glaucoma
- Are taking certain medications that affect dopamine
Can I take prochlorperazine if I’m pregnant or breastfeeding?
Prochlorperazine isn’t usually recommended during pregnancy or breastfeeding unless advised by a doctor. If you’re pregnant or planning to conceive, speak to your doctor about alternative treatments.
What if I miss a dose?
If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not take two doses at once.
How effective is prochlorperazine?
Prochlorperazine is highly effective at treating nausea, vertigo, and dizziness, usually working within 30 to 60 minutes.
What should I do if I take too much?
Taking too much prochlorperazine can cause drowsiness, low blood pressure, uncontrolled movements, or severe dizziness. If you think you’ve taken too much, seek emergency medical help immediately.
What dose of prochlorperazine is usually taken?
- For nausea and vomiting: 5mg to 10mg up to three times daily
- For vertigo: 5mg three times daily, increasing if needed
- For anxiety (short-term use): 15mg to 20mg daily in divided doses
Your doctor will decide the correct dose based on your condition.
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What are the side effects of prochlorperazine?
Common side effects include:
- Drowsiness or dizziness
- Dry mouth
- Blurred vision
- Constipation
- Low blood pressure when standing up (postural hypotension)
Serious side effects, such as muscle stiffness, uncontrollable movements, or severe allergic reactions, require urgent medical attention.
How should I take prochlorperazine?
Prochlorperazine is taken as tablets, buccal tablets (placed between the gum and cheek), or injections, depending on the condition being treated.
When should prochlorperazine be taken?
Prochlorperazine is usually taken when needed for nausea or regularly for longer-term conditions like vertigo or anxiety. Follow your doctor’s instructions carefully.
What are the brand names for prochlorperazine?
Prochlorperazine is available as a generic medicine, but some branded versions include:
- Stemetil
- Buccastem (for nausea and vertigo)
Final thoughts
Prochlorperazine is an effective treatment for nausea, vertigo, and certain mental health conditions. To get the best results, take it as prescribed and avoid alcohol, as it can increase drowsiness. If symptoms persist or side effects become severe, speak to your doctor or pharmacist.
